Eric Dane, the American actor widely recognized for his breakout role as Dr. Mark Sloan (“McSteamy”) on Grey’s Anatomy, has died at the age of 53. He passed away on Thursday, February 19, 2026, after a months-long public battle with amyotrophic lateral sclerosis (ALS) a progressive neurodegenerative disease.
Dane’s family confirmed the news in a heartfelt statement shared with media outlets. They said he spent his final days surrounded by loved ones including his wife, Rebecca Gayheart, and their two daughters, Billie and Georgia. In asking for privacy, the family also highlighted his unwavering courage and advocacy throughout his illness.
ALS announcement
In April 2025, Dane publicly revealed his diagnosis of amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, in an interview with People. ALS is a debilitating condition that affects nerve cells in the brain and spinal cord, leading to progressive muscle weakness and eventual loss of coordination. Despite its severity, Dane expressed gratitude for the support of his family and maintained his intention to continue working.
Soon after disclosing his diagnosis, Dane continued to film the third season of HBO’s Euphoria, in which he starred as Cal Jacobs a role that had gained critical acclaim. His participation in the show demonstrated his commitment to his craft despite the physical challenges he faced.
Rapid progression
Within months of the public announcement, Dane’s condition progressed substantially. He lost the use of his right arm by mid-2025 and began using a wheelchair full-time by October, as reported by multiple outlets. ALS typically leads to worsening symptoms over time, and individuals often lose the ability to walk, speak, or perform basic daily functions without assistance.
In several interviews and appearances, Dane spoke candidly about his experience of living with ALS, describing the reality of the disease as “so horrible.” He shared moments of vulnerability but also strength discussing, for example, how he continued acting after his diagnosis and reflected on how ALS changed his perspective on life and mortality.
ALS awareness and fundraising
As Dane’s condition progressed, he became an outspoken advocate for ALS awareness and research. He appeared at public events and panel discussions, often using his platform to highlight the urgent need for funding and improved medical support for those affected by the disease.
In June 2025, Dane addressed a news conference about challenges patients face with health insurance and access to treatment, speaking not just as an actor but as someone battling ALS. Later that year, he received recognition from the ALS Network, which honored him for his advocacy work.
His advocacy extended to legislative awareness too, as he promoted the importance of continued funding for ALS research and critical therapies that can slow disease progression.
Final Public Appearances
One of Dane’s final public engagements was a virtual panel in late December 2025 hosted by I AM ALS and Synapticure, where he spoke about the physical and emotional toll of ALS. His openness in discussing his own struggles helped bring wider attention to the condition and inspired both patients and caregivers.
Roots and rise to fame
Born on November 9, 1972, in San Francisco, California, Dane began acting in the early 1990s, securing guest roles on shows like The Wonder Years, Saved by the Bell, and Married… with Children. His breakthrough came in 2005 when he was cast as Dr. Mark Sloan on Grey’s Anatomy. The character, also known by fans as “McSteamy,” quickly became one of the show’s most beloved figures.
During his tenure on Grey’s Anatomy (2006–2012), Dane’s charisma and powerful performance made him a household name. After leaving the series, he continued to build his career with roles in film and television, including appearances in The Last Ship, X-Men: The Last Stand, Marley & Me, Valentine’s Day, and Burlesque.
Personal life
In his personal life, Dane married actress Rebecca Gayheart in 2004. They shared two daughters, Billie and Georgia. Although the couple separated and Gayheart filed for divorce in 2018, she later moved to dismiss the divorce filing around the time of Dane’s ALS diagnosis, remaining a central figure in his care and support network.
Eric Dane’s passing marks the end of a remarkable and multidimensional life one that was defined not only by memorable performances on screen but also by resilience, advocacy, and the willingness to confront one of the world’s most devastating diseases with honesty and courage. His legacy lives on through his contributions to entertainment and his efforts to raise awareness for ALS, offering hope and visibility to countless others affected by the condition.